ZSX 1st Quarter 2011 Newsletter

Spring Greetings from ZSX Medical!

ZSX Medical has been busy this past winter, and this newsletter gives you a taste of some of our most significant activities, as well as a few upcoming events. We usually end our newsletter with a discussion of some aspect of cesarean delivery; this time, we will close with a discussion of hysterectomy, another major procedure in women’s health.

ZSX Medical and Obstetricians Collaborate at 2011 Society for Maternal-Fetal Medicine Conference

 ZSX Medical met with well over two dozen physicians specializing in caring for mothers and babies at the 31st Annual Meeting of The Society for Maternal-Fetal Medicine this past February in San Francisco, CA. ZSX Medical’s president, Dan Mazzucco, Ph.D., and clinical advisor, Dr. Michael Diamond, had the privilege of meeting up with these experts in the field of maternal-fetal medicine to discuss their surgical needs and the opportunity to apply the Zip-Stitch™ platform to address these needs. ZSX Medical is grateful for clinicians’ willingness to provide their insights and feedback, and we look forward to continuing to collaborate with these physicians in the coming months.

ZSX Medical Deemed “Company Most Likely to Succeed” at NJTC Venture Conference

 ZSX Medical is honored to have been selected as the “Company Most Likely to Succeed” at the annual Venture Conference of the New Jersey Technology Council. Held on March 25th at The Palace at Somerset Park, the Venture Conference is NJTC’s annual marquee event. This year’s Conference featured more than 60 diverse start-up ventures, hailing from around the nation, and ranging from social networking, nutrition and green-tech to budding medical device and pharmaceutical companies. Emerging with this top honor amidst an excellent field of contenders attests to the progress ZSX Medical has made thus far in developing an innovative technology with a large market opportunity. Click here for the official press release from NJTC. The photo on the right shows company President, Dan Mazzucco, receiving the award from David Sorin, of Sorin Royer Cooper, one of the event sponsors.

ZSX Medical Secures $50,000 from Ben Franklin Technology Partners

ZSX Medical successfully obtained a $50,000 debt instrument from Ben Franklin Technology Partners (BFTP) of Southeast Pennsylvania as part of BFTP’s Technology Commercialization Fund. This furthers ZSX Medical’s relationship with BFTP; BFTP had previously provided a grant to support early development of Zip-Stitch™. ZSX Medical is pleased to partner with the Commonwealth of Pennsylvania as we continue to progress, promoting economic development in the Delaware Valley.

ZSX Medical Continues Pre-clinical Prototype Testing

ZSX Medical is conducting a series of laboratory studies on the Zip-Stitch™ clip after successfully engineering and molding a second-generation clip prototype last quarter. As always for these studies, we are relying on our top-notch industrial and academic partners. Assisting us in these studies are Synectic Medical Products Development and Synechion, Inc., which are premier surgical tool engineering and testing partners, as well as Mark Nicosia, Ph.D., chair of Mechanical Engineering at Widener University.

Keeping in Touch

ZSX Medical is reachable through www.zsxmedical.com or www.ZipStitch.com. In addition, we will be attending the 59th Annual Clinical Meetingof the American College of Obstetricians and Gynecologists.If you will be attending this event, please let us know; we would be happy to get together during the conference.

Dan Mazzucco, President & CTO
Eric Rugart, COO

 

And now for our examination of an important topic in women's health...

Hysterectomy

Hysterectomy is the surgical removal of the uterus. It is the second most common large incision surgery performed on women in the U.S., at about 600,000 per year.1 Hysterectomy is performed to treat various conditions including uterine fibroids, endometriosis, cancer, chronic pelvic pain, uterine prolapse and abnormal uterine bleeding.2 Before choosing hysterectomy, other treatment options are usually explored first, since the patient loses her ability to become pregnant after the procedure.

Laparoscopic Hysterectomy: An Increasing Trend


There are a number of ways to approach hysterectomy, from a large abdominal incision (laparotomy or “open” hysterectomy) to very small incisions (laparoscopy) to no external incision (vaginal). Many factors affect the approach that a surgeon will take. Historically two of every three hysterectomies were performed using laparotomy,3 which has higher rates of complications, a slower and more painful recovery, and a longer hospitalization than laparoscopy.4-6 However, patients and doctors alike have worked to increase the fraction of hysterectomies performed via laparoscopy; including outpatient procedures, more than 40% of hysterectomies are currently performed via laparoscope.3 As surgical technology and technique continue to improve, we expect this trend toward less invasive hysterectomy to continue.

Technical Challenges in Laparoscopy


The transition from open laparotomy to less invasive procedures has been hindered by the fact that it’s just not easy to do this surgery through tiny holes in the abdomen. It takes 30 to 60 minutes longer to do the procedure laparoscopically.5-7 One of the most difficult parts of laparoscopic hysterectomy is closing the “vaginal cuff,” which is the incised surface that remains after the uterus is removed. Often, the vaginal cuff doesn’t heal well after laparoscopy, leading to a serious complication called dehiscence. Dehiscence occurs in one in 20 women after laparoscopic hysterectomy, but is virtually non-existent in laparotomy.8 Vaginal cuff dehiscenceleads to pain and bleeding, and requires reoperation for repair.8-9

Where ZSX Medical Fits In


Many patients who might otherwise be candidates for laparoscopy are undergoing a more difficult procedure because laparoscopy is too technically challenging. Others are undergoing laparoscopy, but suffering dehiscence or other complications. ZSX Medical sees it as our responsibility to help advance the science of wound closure in hysterectomy, improving clinical outcomes in patients and reducing the costs associated with longer hospitalizations.

For more information regarding Zip-Stitch™, email us at info@zsxmedical.com. Click HERE to subcribe to our quarterly newsletter.

Bibliography

  1. Whiteman MK, Hillis SD, Jamieson DJ, et al. Inpatient hysterectomy surveillance in the United States, 2000-2004. Am J Obstet Gynecol2008;198:34.e1-34.e7.
  2. http://www.acog.org/publications/patient_education/bp008.cfm.
  3. HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality. Available at: http://hcupnet.ahrq.gov/. Accessed March 8, 2011. 
  4. Candiani M, Izzo S, Bulfoni A, Riparini J, Ronzoni S, Marconi A. Laparoscopic vs vaginal hysterectomy for benign pathology. American journal of obstetrics and gynecology. 2009;200(4):368 e361-367.
  5. Loh FH, Koa RC. Laparoscopic hysterectomy versus abdominal hysterectomy: a controlled study of clinical and functional outcomes. Singapore medical journal. 2002;43(8):403-407.
  6. Boggess JF, Gehrig PA, Cantrell L, Shafer A, Ridgway M, Skinner EN, Fowler WC. A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy. American journal of obstetrics and gynecology. 2008;199(4):360 e361-369.
  7. Falcone T, Paraiso MF, Mascha E. Prospective randomized clinical trial of laparoscopically assisted vaginal hysterectomy versus total abdominal hysterectomy. American journal of obstetrics and gynecology. 1999;180(4):955-962.
  8. Kho RM, Akl MN, Cornella JL, Magtibay PM, Wechter ME, Magrina JF. Incidence and characteristics of patients with vaginal cuff dehiscence after robotic procedures. Obstetrics and gynecology. 2009;114(2 Pt 1):231-235.
  9. Nezhat CH, Nezhat F, Seidman DS, Nezhat C. Vaginal vault evisceration after total laparoscopic hysterectomy. Obstetrics and gynecology. 1996;87(5 Pt 2):868-870.