ZSX 1st Quarter 2010 Newsletter

Welcome to Spring! As the new season dawns upon us, so arrives a new edition of the quarterly newsletter from ZSX Medical. We send this newsletter only to those who have requested to be updated as to our company's progress. As always, in this newsletter, we will briefly outline a few key developments in our company over the past three months, and discuss a clinical topic. In this issue, the topic is the importance of surgical time in cesarean delivery.

Recent News

1. Earlier this month, ZSX Medical convened an expert panel to review and refine our development strategy surrounding the Zip-Stitch™ uterine closure device. The panel brought together expertise in clinical practice, post-surgical complications, clinical trials, regulatory pathways, medical device pricing and reimbursement, and hospital purchasing. The meeting enabled us to confirm and refine our development strategy as we move forward in product development. This meeting was made possible through the sponsorship of BioStrategy Partners, a regional non-profit organization committed to aiding start-up life science companies like ZSX Medical.

2. ZSX Medical is honored to be one of a select group of companies chosen to present at the Angel Venture Fair on April 6, 2010. The Angel Venture Fair is held at the Union League in Philadelphia, PA, and hosted by the Private Investors Forum, a regional consortium of angel investors and investor groups. We encourage accredited investors who have been following ZSX Medical to attend our talk and stop by our booth at this conference. You can register for the conference here or find out more information here. Discounted registration is available until April 1. We look forward to this opportunity to present our company to the investment community.

Why Surgical Time Matters

In an effort to keep our audience abreast of the key issues in cesarean delivery, we're dedicating this section of the newsletter to the issue of surgical time. The top priority in any cesarean delivery is to safely bring the baby into the world with minimal injury to the mother. So why does surgical time matter? Time always matters in surgery. A longer surgery means more anesthesia, greater risk of getting an infection, and more bleeding, all things that the doctors and nurses are working hard to avoid.

In cesarean delivery, time can be critical, depending on the reason for the cesarean. If the doctors suspect the baby is having difficulty getting oxygen, they may be performing a cesarean delivery so that they can treat the baby. In that case, time becomes paramount to the baby's safety. Even in routine cesarean deliveries, bleeding, risk of infection, and duration of anesthesia are important to the safety of the mother. And all are tied to surgical time.

So how long does a cesarean delivery take? A cesarean delivery can take anywhere from 20 minutes to more than an hour. The duration of surgery depends on a number of factors, ranging from the type of hospital to surgical technique to whether the mother has had adhesions from a previous cesarean delivery. For the sake of discussion, let's consider an uncomplicated cesarean delivery that takes 30 minutes, from first incision to skin closure. That may not seem like a long time, but when you consider that the delivery itself takes about two minutes, and the other 28 minutes are opening and closing the wounds, you'll see that we do a lot of opening and closing for a two-minute procedure.

Breakdown of Cesarean Delivery Time

The figure above is a breakdown of how long it takes to do all that needs to be done during a typical 30 minute cesarean delivery.[1] About one fourth of the time (eight minutes) is taken up in closing the uterus. This time period can be the most critical for the mother, because this is the time that the uterus is open and bleeding, and this is the time that bacteria can spread from the uterus.

At ZSX Medical, we think there is an opportunity to reduce this critical time during cesarean delivery, and we are trying to address the amount of time it takes to close the uterus. In addition to the significant benefits of reduced risk of infection, reduced bleeding, and reduced anesthesia time, an improvement in this area would decrease hospital staffing costs and operating room costs.

Keeping in Touch

Thanks for reading our newsletter. We'll check back in a few months from now. In the meantime, ZSX Medical is reachable through www.ZSXMedical.com or www.ZipStitch.com. We may use our siteperiodically as a mechanism to keep interested parties informed as to our progress. Check back often!

Sincerely,

Dan Mazzucco, President & CTO
Eric Rugart, COO

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Bibliography

1. Tulandi T, Agdi M, Zarei A, Miner L, Sikirica V. Adhesion development and morbidity after repeat cesarean delivery. American journal of obstetrics and gynecology. 2009;201(1):56 e51-56.

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